Polymorphism of the parasite lactate dehydrogenase gene from Plasmodium vivax Korean isolates
نویسندگان
چکیده
منابع مشابه
dna sequence polymorphism of the lactate dehydrogenase gene¬from iranian plasmodium vivax and plasmodium falcipa¬rum isolates
background: parasite lactate dehydrogenase ( p ldh) is extensively employed as malaria rapid diagnostic tests (rdts). moreover, it is a well-known drug target candidate. however, the genetic diversity of this gene might influence performance of rdt kits and its drug target candidacy. this study aimed to determine polymorphism of p ldh gene from iranian isolates of p. vivax and p. falciparum. m...
متن کاملDNA Sequence Polymorphism of the Lactate Dehydrogenase Genefrom Iranian Plasmodium vivax and Plasmodium falciparum Isolates
BACKGROUND Parasite lactate dehydrogenase (pLDH) is extensively employed as malaria rapid diagnostic tests (RDTs). Moreover, it is a well-known drug target candidate. However, the genetic diversity of this gene might influence performance of RDT kits and its drug target candidacy. This study aimed to determine polymorphism of pLDH gene from Iranian isolates of P. vivax and P. falciparum. METH...
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Vivax malaria reemerged in Korea in 1993 and the outbreak has been continued with fluctuating numbers of annual indigenous cases. Understanding the nature of the genetic population of Plasmodium vivax circulating in Korea is beneficial for the knowledge of the nationwide parasite heterogeneity and in the implementation of malaria control programs in the country. Previously, we analyzed polymorp...
متن کاملMolecular genetic characterization of the merozoite surface protein 1 Gene of Plasmodium vivax from reemerging Korean isolates.
Plasmodium vivax merozoite surface protein 1 (PvMSP-1) has been considered a major candidate for the development of an antimalaria vaccine, but the molecule exhibits antigenic diversity among isolates. The extent of genetic polymorphism in the region between interspecies conserved blocks 4 and 5 (ICB4 and ICB5) of the PvMSP-1 gene was analyzed for 30 Korean isolates. Two genotypes, SK-A and SK-...
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ژورنال
عنوان ژورنال: Malaria Journal
سال: 2013
ISSN: 1475-2875
DOI: 10.1186/1475-2875-12-166